SEC FORM 3 SEC Form 3
FORM 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
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1. Name and Address of Reporting Person*
Hindman James M.

(Last) (First) (Middle)
C/O SIENNA BIOPHARMACEUTICALS, INC.
30699 RUSSELL RANCH ROAD, SUITE 140

(Street)
WESTLAKE VILLAGE CA 91362

(City) (State) (Zip)
2. Date of Event Requiring Statement (Month/Day/Year)
08/01/2018
3. Issuer Name and Ticker or Trading Symbol
Sienna Biopharmaceuticals, Inc. [ SNNA ]
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director 10% Owner
Officer (give title below) Other (specify below)
5. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Explanation of Responses:
Remarks:
No securities are beneficially owned.
/s/ Timothy K. Andrews, as attorney-in-fact for James M. Hindman 08/03/2018
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
Sienna Biopharmaceuticals, Inc.

Power of Attorney

	Know all by these presents, that the undersigned hereby 
constitutes and appoints each of (i) the Chief Executive Officer of 
Sienna Biopharmaceuticals, Inc., a Delaware corporation (the 
"Company"), who is currently Frederick C. Beddingfield III, (ii) the 
Company's Chief Financial Officer, who is currently John W. Smither, 
and (iii) the Company's General Counsel, who is currently Timothy K. 
Andrews, and their respective successors (including anyone serving in 
such capacities on an interim or acting basis), signing singly, with 
full powers of substitution, as the undersigned's true and lawful 
attorney-in-fact to:
1.	prepare, execute in the undersigned's name and on the 
undersigned's behalf, and submit to the U.S. Securities and 
Exchange Commission (the "SEC") a Form ID, including amendments 
thereto, and any other documents necessary or appropriate to 
obtain codes and passwords enabling the undersigned to make 
electronic filings with the SEC of reports required by Section 
16(a) of the Securities Exchange Act of 1934 or any rule or 
regulation of the SEC;
2.	execute for and on behalf of the undersigned, in the 
undersigned's capacity as an officer and/or director of the 
Company, Forms
 3, 4, and 5 and any amendments thereto in 
accordance with Section 16(a) of the Securities Exchange Act of 
1934 and the rules thereunder;
3.	do and perform any and all acts for and on behalf of the 
undersigned which may be necessary or desirable to complete and 
execute any such Form 3, 4, or 5, complete and execute any 
amendment or amendments thereto, and timely file such form with 
the SEC and any stock exchange or similar authority; and
4.	take any other action of any type whatsoever in connection with 
the foregoing which, in the opinion of such attorney-in-fact, 
may be of benefit to, in the best interest of, or legally 
required by, the undersigned, it being understood that the 
documents executed by such attorney-in-fact on behalf of the 
undersigned pursuant to this Power of Attorney shall be in such 
form and shall contain such terms and conditions as such 
attorney-in-fact may approve in such attorney-in-fact's 
discretion.
      The undersigned hereby grants to each such attorney-in-fact full 
power and authority to do and perform any and every act and thing 
whatsoever requisite, necessary, or proper to be done in the exercise 
of any of the rights and powers herein granted, as fully to all 
intents and purposes as the undersigned might or could do if 
personally present, with full power of substitution or revocation, 
hereby ratifying and confirming all that such attorney-in-fact, or 
such attorney-in-fact's substitute or substitutes, shall lawfully do 
or cause to be done by virtue of this power of attorney and the 
rights and powers herein granted. The undersigned acknowledges that 
the foregoing attorneys-in-fact, in serving in such capacity at the 
request of the undersigned, are not assuming, nor is the Company 
assuming, any of the undersigned's responsibilities to comply with 
Section 16 of the Securities Exchange Act of 1934.
	This Power of Attorney shall remain in full force and effect 
until the undersigned is no longer required to file Forms 3, 4, and 5 
with respect to the undersigned's holdings of and transactions in 
securities issued by the Company, unless earlier revoked by the 
undersigned in a signed writing delivered to the foregoing attorneys-
in-fact.
	IN WITNESS WHEREOF, the undersigned has caused this Power of 
Attorney to be executed as of this 31st day of July, 2018.

/s/James M. Hindman				
By: James M. Hindman


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