Sienna Biopharmaceuticals to Present at Dermatology Drug Development Summit Europe
About the Presentations
Title:“Bridging the Innovation Gap in the Treatment of Mild to Moderate Dermatological Diseases”
Presenter: Dr. Lizzul
Date and Time:
• Addressing the unmet need in topical drug development towards a large patient population with mild to moderate dermatological diseases, still primarily using topical steroids
• Updating on SNA-120 (TrkA inhibitor) – SNA-120, a novel approach to the treatment of psoriasis, targeting NGF/TrkA and neurogenic inflammation
– The important role of nerves & neuropeptides in psoriasis
– Itch as a proxy clinical biomarker for high NGF/TrkA expression in psoriasis
– A novel non-steroidal approach in the treatment of psoriasis and associated itch targeting the NGF/TrkA pathway
Title:“The Topical-by-Design Technology – Defying Conventional Wisdom”
Presenter: Dr. Traversa
Date and Time:
• Does size really matter?
• Exploring an innovative way of using polymers
• Bringing potent drugs to derm fruition, minimizing systemic exposure
Dr. Traversa will also participate in the opening keynote panel discussion, “What’s Next in
SNA-120 (pegcantratinib) is Sienna’s Phase 3 topical, non-steroidal Tropomyosin receptor kinase A (TrkA) inhibitor under investigation for the treatment of psoriasis. TrkA is the high-affinity receptor for nerve growth factor (NGF). SNA-120 selectively targets the NGF-TrkA signaling pathway, which plays an important role in the pathogenesis of psoriasis and pruritus (itch). SNA-120 was developed using Sienna’s innovative proprietary technology platform (see About Topical by Design™ below).
SNA-120 (0.05%) demonstrated in a Phase 2b clinical trial statistically significant improvement compared to vehicle on important pre-specified endpoints of psoriasis disease severity, including the Investigator’s Global Assessment (IGA) 2-grade composite, comprising a 2-grade improvement from baseline and clear (0) or almost clear (1) skin, which has been the Phase 3 primary endpoint for topical psoriasis drugs approved by the
As part of the Phase 2 trial, biopsy analyses were conducted at
Following a positive End-of-Phase 2 (EOP2) meeting with the
About Topical by Design™
Topical by Design™ is Sienna’s innovative proprietary technology platform, which applies a scientific design process to create potent targeted pharmacologically active molecules that are directed toward a specific target tissue and a select disease pathway, and with minimal to no systemic exposure. By stably linking a short polyethylene glycol (PEG) polymer to a pharmacologically active molecule, Sienna’s technology platform alters the mechanism of action of the starting pharmaceutical ingredient and refines its target selectivity, enabling highly localized drug concentration in various target tissues, while dramatically minimizing systemic exposure. This approach of providing efficacy without compromising safety has unlocked a pipeline of selective tissue–targeted kinase inhibitors (TTKI) that target select pathways in specific tissues to treat a variety of chronic inflammatory and immunologic conditions.
For more information, visit the Company’s website at www.SiennaBio.com.
This press release contains forward-looking statements, including but not limited to statements regarding Sienna’s SNA-120 Phase 2b data and the progress and timing of Sienna’s SNA-120 development, including anticipated enrollment in the Phase 3 program for SNA-120. Such forward-looking statements involve substantial risks and uncertainties that could cause Sienna’s clinical development programs, future results, performance or achievements to differ significantly from those expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the uncertainties inherent in the pharmaceutical drug and medical device development processes, including regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing pharmaceutical drug and medical device products, Sienna’s ability to raise sufficient capital to fund its development programs, and other matters that could affect the sufficiency of existing cash to fund operations and the availability or commercial potential of Sienna’s drug candidates. Sienna undertakes no obligation to update or revise any forward-looking statements. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to the business of Sienna in general, see Sienna’s most recent Annual Report on Form 10-K and any subsequent current and periodic reports filed with the
Source: Sienna Biopharmaceuticals, Inc.