Sienna Biopharmaceuticals Announces SNA-120 (0.05%) Biopsy Data Demonstrate Positive Impact on Key Inflammatory Cytokines, including IL-23 and IL-17, in Psoriasis
-- Biopsy data support strong clinical effect observed in Phase 2 trials with SNA-120
-- Following Positive End-of-Phase 2 meeting with
“The clear and substantial impact by Sienna’s SNA-120 on immune cells and the vast array of important psoriasis-related pathways after 12 weeks of treatment is impressive and encouraging for a topical, non-steroidal treatment,” said
- Specifically, the Immunohistochemistry analysis showed meaningful and statistically significant improvement in the epidermal thickness at Week 12, supporting the effect of SNA-120 (0.05%) on keratinocyte hyperproliferation and inflammation. In addition, the data demonstrated a statistically significant reduction in T cell and dendritic cell counts, confirming an immune response to treatment with SNA-120.
- In MicroArray analyses, SNA-120 (0.05%) was also observed to affect most of the key inflammatory pathways in psoriasis (40 of 45) in a statistically significant manner when compared to vehicle at Week 12.
- In the qRT-PCR analysis, SNA-120 (0.05%) demonstrated substantial, statistically significant gene expression improvements in key cytokines that play an important role in psoriasis pathogenesis, including IL-23, IL-12, IL-17A and IFNg, among other cytokines, in PASI 75 responders and even led to restoration to non-lesional expression levels, further validating the strong pharmacological effect of SNA-120.
“We are pleased to report these histological and biomarker results from our recent Phase 2b trial with SNA-120, our tissue-targeted TrkA inhibitor,” said
About SNA-120 Phase 2b Trial Results
SNA-120 (0.05%) demonstrated in a Phase 2b clinical trial statistically significant improvement compared to vehicle on important pre-specified endpoints of psoriasis disease severity, including the Investigator’s Global Assessment (IGA) 2-grade composite, comprising a 2-grade improvement from baseline and clear (0) or almost clear (1) skin, which has been the Phase 3 primary endpoint for topical psoriasis drugs approved by the
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This press release contains forward-looking statements, including but not limited to statements regarding Sienna’s SNA-120 biopsy data and the progress and timing of Sienna’s SNA-120 development, including anticipated enrollment in the Phase 3 program for SNA-120. Such forward-looking statements involve substantial risks and uncertainties that could cause Sienna’s clinical development programs, future results, performance or achievements to differ significantly from those expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the uncertainties inherent in the pharmaceutical drug and medical device development processes, including regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing pharmaceutical drug and medical device products, Sienna’s ability to raise sufficient capital to fund its development programs, and other matters that could affect the sufficiency of existing cash to fund operations and the availability or commercial potential of Sienna’s drug candidates. Sienna undertakes no obligation to update or revise any forward-looking statements. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to the business of Sienna in general, see Sienna’s most recent Annual Report on Form 10-K and any subsequent current and periodic reports filed with the
Source: Sienna Biopharmaceuticals, Inc.