Sienna Biopharmaceuticals to Present SNA-125 Pre-Clinical Psoriasis Data as Late-Breaker at the International Investigative Dermatology Congress
SNA-125 is Sienna’s second unique drug candidate created from the Company’s proprietary Topical by Design™ technology, which optimizes small molecules for topical administration, balancing the benefits of high local drug concentration with low systemic exposure.
SNA-125 is a selective kinase inhibitor that inhibits Janus kinase 3, or JAK3, and tropomyosin receptor kinase A, or TrkA. JAK3 is required for immune cell development, and inhibiting JAK3 blocks the signaling of key cytokines, such as interleukin-2, or IL-2, IL-4, IL-17A, IL-17F and tumor necrosis factor-alpha, or TNF-α, in T cells and NK cells, and results in a reduction in the severity of autoimmune and inflammatory diseases in which those cytokines play a pivotal role. JAK3 is a validated target in psoriasis, atopic dermatitis and pruritus. TrkA is the high affinity receptor for nerve growth factor, or NGF, a known mediator of neurogenic inflammation and itch associated with psoriasis.
This press release contains forward-looking statements, including but not limited to statements regarding the timing of data readouts from Sienna’s Phase 1/2 proof-of-concept clinical trials of SNA-125. Such forward-looking statements involve substantial risks and uncertainties that could cause Sienna’s clinical development programs, future results, performance or achievements to differ significantly from those expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the uncertainties inherent in the drug development process, including the clinical trial enrollment process, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, Sienna’s ability to successfully protect and defend its intellectual property, and other matters that could affect the sufficiency of existing cash to fund operations and the availability or commercial potential of Sienna’s product candidates. Sienna undertakes no obligation to update or revise any forward-looking statements. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to the business of the Company in general, see Sienna’s most recent Quarterly Report on Form 10-Q and any subsequent current and periodic reports filed with the
Source: Sienna Biopharmaceuticals, Inc.